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Among these metabolites, the overall ATP and NADPH pool sizes were found to be significantly higher in the M2 phenotype with the major contribution from OXPHOS

Furthermore, the apoptosis of SGNs detected by C-CASP3 immunostaining and western blot showed that there was much less C-CASP3-positive SGNs and remarkable reduction of the C-CASP3 protein levels in the NAC co-treated groups compared with the peroxynitrite-only groups, and it was also lower in the peroxynitrite + gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figures 7B,C)

SLC7A11 is the primary transporter protein, highly specific for cystine and glutamate, while SLC3A2 is a chaperone